Bortezomib
Bortezomib is a potent 20S proteasome inhibitor with Ki of 0.6 nM. It exhibits favorable selectivity towards tumor cells over normal cells. Bortezomib (PS-341) inhibits NF-κB and induces ERK phosphorylation to suppress cathepsin B and inhibit the catalytic process of autophagy in ovarian cancer and other solid tumors.
| Trivial name | LDP-341, MLM341, NSC 681239,PS-341 |
| Catalog Number | S1013 |
| Molecular Formula | C19H25BN4O4 |
| CAS# | 179324-69-7 |
| Inchi | InChI=1S/C19H25BN4O4/c1-13(2)10-17(20(27)28)24-18(25)15(11-14-6-4-3-5-7-14)23-19(26)16-12-21-8-9-22-16/h3-9,12-13,15,17,27-28H,10-11H2,1-2H3,(H,23,26)(H,24,25)/t15-,17-/m0/s1 |
| Inchi Key | GXJABQQUPOEUTA-RDJZCZTQSA-N |
| SMILES | B(C(CC(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C2=NC=CN=C2)(O)O |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/Bortezomib.html |
| Additional Information | https://file.selleck.cn/downloads/struct/Bortezomib-Velcade-chemical-structure-S1013.gif |