α-Conotoxin MII
α-Conotoxin MII is a nicotinic acetylcholine receptor antagonist. It is highly potent, selective and competitive for α3β2 subunit. Its IC50 value is 0.5-3.5 nM at α3β2 expressed in Xenopus oocytes. It also potently prevents β3-containing neuronal nicotinic receptors.
| Catalog Number | 175735-93-0 |
| Alternative Name(s) | Alpha-Conotoxin MII; H-Gly-Cys(1)-Cys(2)-Ser-Asn-Pro-Val-Cys(1)-His-Leu-Glu-His-Ser-Asn-Leu-Cys(2)-NH2; glycyl-L-cysteinyl-L-cysteinyl-L-seryl-L-asparagyl-L-prolyl-L-valyl-L-cysteinyl-L-histidyl-L-leucyl-L-alpha-glutamyl-L-histidyl-L-seryl-L-asparagyl-L-leucyl-L-cysteinamide (2->8),(3->16)-bis(disulfide) |
| Molecular Formula | C67H103N23O22S4 |
| CAS# | 175735-93-0 |
| Purity | ≥95% |
| Inchi | InChI=1S/C67H103N23O22S4/c1-29(2)12-35-55(100)77-34(9-10-51(96)97)54(99)80-38(15-33-20-73-28-75-33)58(103)84-41(21-91)60(105)82-39(16-48(69)93)59(104)79-36(13-30(3)4)56(101)86-43(53(71)98)23-113-115-25-45-64(109)85-42(22-92)61(106)83-40(17-49(70)94)67(112)90-11-7-8-47(90)65(110)89-52(31(5)6)66(111)88-46(26-116-114-24-44(62(107)87-45)76-50(95)18-68)63(108)81-37(57(102)78-35)14-32-19-72-27-74-32/h19-20,27-31,34-47,52,91-92H,7-18,21-26,68H2,1-6H3,(H2,69,93)(H2,70,94)(H2,71,98)(H,72,74)(H,73,75)(H,76,95)(H,77,100)(H,78,102)(H,79,104)(H,80,99)(H,81,108)(H,82,105)(H,83,106)(H,84,103)(H,85,109)(H,86,101)(H,87,107)(H,88,111)(H,89,110)(H,96,97)/t34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,52-/m0/s1 |
| Inchi Key | DUQYFGMBLOPGBY-XCQLYXDWSA-N |
| Size | Please inquire |
| Supplier Page | https://aapep.bocsci.com/product/conotoxin-mii-cas-175735-93-0-169602.html |