Exatecan
Exatecan (DX-8951), is a water-soluble derivative of camptothecin. It acts as an inhibitor of DNA topoisomerase I with an IC50 value of 1.906 μM. It demonstrates potent antitumor effects and triggers apoptotic cell death after treatment in human pancreatic cancer cells.
| Trivial name | DX-8951 |
| Catalog Number | E5775 |
| Molecular Formula | C37H42F2N8O4 |
| CAS# | 171335-80-1 |
| Inchi | InChI=1S/C37H42F2N8O4/c1-3-35(26(2)48)47-36(49)46(25-42-47)31-7-5-29(6-8-31)43-14-16-44(17-15-43)30-9-11-32(12-10-30)50-20-27-19-37(51-21-27,22-45-24-40-23-41-45)33-13-4-28(38)18-34(33)39/h4-13,18,23- 27,35,48H,3,14-17,19-22H2,1-2H3/t26-,27+,35-,37-/m0/s1 |
| Inchi Key | RAGOYPUPXAKGKH-XAKZXMRKSA-N |
| SMILES | CCC(C(C)O)N1C(=O)N(C=N1)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)OCC5CC(OC5)(CN6C=NC=N6)C7=C(C=C(C=C7)F)F |
| Size | 1g |
| Supplier Page | http://www.selleckchem.com/products/exatecan.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E5775-Exatecan-chemical-structure.png |