Roblitinib (FGF401)
Roblitinib (FGF401) is an FGFR4-selective inhibitor with an IC50 of 1.9 nM. It binds in a reversible covalent manner to the FGFR4 kinase domain and shows at least 1,000 fold selectivity against of panel of 65 kinases in biochemical assays.
Trivial name | N/A |
Catalog Number | S8548 |
Molecular Formula | C25H30N8O4 |
CAS# | 1708971-55-4 |
Inchi | InChI=1S/C25H30N8O4/c1-31-7-8-32(23(35)15-31)14-18-10-17-4-3-6-33(24(17)29-21(18)16-34)25(36)30-22-11-20(27-5-9-37-2)19(12-26)13-28-22/h10-11,13,16H,3-9,14-15H2,1-2H3,(H2,27,28,30,36) |
Inchi Key | BHKDKKZMPODMIQ-UHFFFAOYSA-N |
SMILES | CN1CCN(C(=O)C1)CC2=C(N=C3C(=C2)CCCN3C(=O)NC4=NC=C(C(=C4)NCCOC)C#N)C=O |
Size | 100mg |
Supplier Page | http://www.selleckchem.com/products/fgf401.html |
Additional Information | https://file.selleck.cn/downloads/struct/fgf401-chemical-structure-s8548.gif |