Avapritinib
Avapritinib is a small molecule kinase inhibitor that potently inhibits PDGFRα D842V mutant activity in vitro (IC50 = 0.5 nM) and PDGFRα D842V autophosphorylation in the cellular setting (IC50 = 30 nM); also a potent inhibitor of the analogous Kit (c-Kit) mutation, D816V in Kit (c-Kit) Exon 17 (IC50 = 0.5 nM).
| Trivial name | BLU-285 |
| Catalog Number | S8553 |
| Molecular Formula | C26H27FN10 |
| CAS# | 1703793-34-3 |
| Inchi | InChI=1S/C26H27FN10/c1-26(28,20-3-5-22(27)6-4-20)21-13-29-25(30-14-21)36-9-7-35(8-10-36)24-23-11-18(16-37(23)33-17-31-24)19-12-32-34(2)15-19/h3-6,11-17H,7-10,28H2,1-2H3/t26-/m0/s1 |
| Inchi Key | DWYRIWUZIJHQKQ-SANMLTNESA-N |
| SMILES | CC(C1=CC=C(C=C1)F)(C2=CN=C(N=C2)N3CCN(CC3)C4=NC=NN5C4=CC(=C5)C6=CN(N=C6)C)N |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/blu-285.html |
| Additional Information | https://file.selleck.cn/downloads/struct/blu-285-chemical-structure-s8553.gif |