H3B-6527
H3B-6527 is a highly selective covalent FGFR4 inhibitor with an IC50 value of <1.2 nM and at least 250-fold selectivity over FGFR1-3 (IC50 values of 320, 1,290 and 1,060 nM respectively).
| Trivial name | N/A |
| Catalog Number | S8675 |
| Molecular Formula | C29H34Cl2N8O4 |
| CAS# | 1702259-66-2 |
| Inchi | InChI=1S/C29H34Cl2N8O4/c1-6-25(40)35-20-14-18(39-12-10-38(7-2)11-13-39)8-9-19(20)34-23-16-24(33-17-32-23)37(3)29(41)36-28-26(30)21(42-4)15-22(43-5)27(28)31/h6,8-9,14-17H,1,7,10-13H2,2-5H3,(H,35,40)(H, 36,41)(H,32,33,34) |
| Inchi Key | MBWRLLRCTIYXDW-UHFFFAOYSA-N |
| SMILES | CCN1CCN(CC1)C2=CC(=C(C=C2)NC3=CC(=NC=N3)N(C)C(=O)NC4=C(C(=CC(=C4Cl)OC)OC)Cl)NC(=O)C=C |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/h3b-6527.html |
| Additional Information | https://file.selleck.cn/downloads/struct/h3b-6527-chemical-structure-s8675.gif |