Fosbretabulin (Combretastatin A4 Phosphate) Disodium
Fosbretabulin (Combretastatin A4 Phosphate) Disodium is the water-soluble prodrug of Combretastatin A4 (CA4), which is a microtubule-targeting agent that binds β-tubulin with Kd of 0.4 μM in a cell-free assay. Fosbretabulin Disodium inhibits the polymerization of tubulin with IC50 of 2.4 μM, and also disrupts tumor vasculature. Fosbretabulin disodium induces mitotic arrest and apoptosis in endothelial cells. Phase 3.
| Trivial name | CA 4DP |
| Catalog Number | S7204 |
| Molecular Formula | C18H19O8P.2Na |
| CAS# | 168555-66-6 |
| Inchi | InChI=1S/C18H21O8P.2Na/c1-22-14-8-7-12(9-15(14)26-27(19,20)21)5-6-13-10-16(23-2)18(25-4)17(11-13)24-3;;/h5-11H,1-4H3,(H2,19,20,21);;/q;2*+1/p-2/b6-5-;; |
| Inchi Key | VXNQMUVMEIGUJW-XNOMRPDFSA-L |
| SMILES | COC1=C(C=C(C=C1)C=CC2=CC(=C(C(=C2)OC)OC)OC)OP(=O)([O-])[O-].[Na+].[Na+] |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/fosbretabulin-disodium-combretastatin-a-4-phosphate-disodium-ca4p-disodium.html |
| Additional Information | https://file.selleck.cn/downloads/struct/fosbretabulin-disodium-combretastatin-a-4-phosphate-disodium-ca4p-disodium-chemical-structure-s7204.gif |