Compound 401
Compound 401 is a synthetic inhibitor of DNA-PK(IC50=0.28 μM) and mTOR (IC50=5.3 μM). It has no inhibition on p110α/p85α PI3K (>100 μM) and blocks the phosphorylation of S6 kinase 1 Thr389 and Akt Ser473 in COS7 cells.
| Trivial name | N/A |
| Catalog Number | S6506 |
| Molecular Formula | C16H15N3O2 |
| CAS# | 168425-64-7 |
| Inchi | InChI=1S/C16H15N3O2/c20-15-11-14(18-7-9-21-10-8-18)17-16-13-4-2-1-3-12(13)5-6-19(15)16/h1-6,11H,7-10H2 |
| Inchi Key | BVRDQVRQVGRNHG-UHFFFAOYSA-N |
| SMILES | C1COCCN1C2=CC(=O)N3C=CC4=CC=CC=C4C3=N2 |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/compound-401.html |
| Additional Information | https://file.selleck.cn/downloads/struct/compound-401-chemical-structure-s6506.gif |