Compound 401
Cell-permeable. A reversible and selective inhibitor of DNA-dependent protein kinase (DNA-PK) (IC50 = 0.28 µM) that also targets mTOR (IC50 = 5. 3µM), but not PI 3-K in vitro. Induces apoptosis in vitro.
| Catalog Number | ABM-003 |
| Alternative Name(s) | 2-(4-Morpholinyl)-4H-pyrimido[2,1-a]isoquinolin-4-one |
| CAS# | 168425-64-7 |
| Inchi | InChI=1S/C16H15N3O2/c20-15-11-14(18-7-9-21-10-8-18)17-16-13-4-2-1-3-12(13)5-6-19(15)16/h1-6,11H,7-10H2 |
| Inchi Key | BVRDQVRQVGRNHG-UHFFFAOYSA-N |
| SMILES | C1COCCN1C2=CC(=O)N3C=CC4=CC=CC=C4C3=N2 |
| Size | Inquiry |
| Supplier Page | https://www.agingclocks.com/compound-401-item-1448.html |