zipalertinib (TAS6417)
zipalertinib (TAS6417) is a novel EGFR inhibitor that targets EGFR exon 20 insertion mutations while sparing wild-type (WT) EGFR. IC50 values ranges from 1.1 ± 0.1 to 8.0 ± 1.1 nmol/L.
Trivial name | CLN-081, TPC-064 |
Catalog Number | S8814 |
Molecular Formula | C23H20N6O |
CAS# | 1661854-97-2 |
Inchi | InChI=1S/C23H20N6O/c1-3-18(30)28-16-8-13(2)21-19(15-9-14-6-4-5-7-17(14)25-10-15)20-22(24)26-12-27-23(20)29(21)11-16/h3-10,12,16H,1,11H2,2H3,(H,28,30)(H2,24,26,27)/t16-/m0/s1 |
Inchi Key | MKCYPWYURWOKST-INIZCTEOSA-N |
SMILES | CC1=CC(CN2C1=C(C3=C(N=CN=C32)N)C4=CC5=CC=CC=C5N=C4)NC(=O)C=C |
Size | 2mg |
Supplier Page | http://www.selleckchem.com/products/tas6417.html |
Additional Information | https://file.selleck.cn/downloads/struct/tas6417-chemical-structure-s8814.gif |