GLPG1837
GLPG1837 (ABBV-974) is a novel CFTR potentiator with an EC50 value of 3 nM for F508del, showing enhanced efficacy on CFTR mutants harboring class III mutations compared to Ivacaftor.
| Trivial name | ABBV-974 |
| Catalog Number | S8698 |
| Molecular Formula | C16H20N4O3S |
| CAS# | 1654725-02-6 |
| Inchi | InChI=1S/C16H20N4O3S/c1-15(2)7-8-10(12(17)21)14(24-11(8)16(3,4)23-15)19-13(22)9-5-6-18-20-9/h5-6H,7H2,1-4H3,(H2,17,21)(H,18,20)(H,19,22) |
| Inchi Key | GHTGYZMBQPXTCQ-UHFFFAOYSA-N |
| SMILES | CC1(CC2=C(C(O1)(C)C)SC(=C2C(=O)N)NC(=O)C3=CC=NN3)C |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/glpg1837.html |
| Additional Information | https://file.selleck.cn/downloads/struct/glpg1837-chemical-structure-s8698.gif |