GW406108X
GW406108X (GW108X) is an inhibitor of Kif15 (Kinesin-12) with an IC50 of 0.82 μM in the ATPase assay. GW406108X inhibits recombinant ULK1 kinase activity with a pIC50 of 6.37 and blocks autophagy in cells, without affecting the upstream signalling kinases mTORC1 and AMPK.
| Trivial name | GW108X |
| Catalog Number | S6953 |
| Molecular Formula | C20H11Cl2NO4 |
| CAS# | 1644443-92-4 |
| Inchi | #N/A |
| Inchi Key | #N/A |
| SMILES | OC1=C(Cl)C=C(C=C1Cl)/C=C/2C(=O)NC3=C2C=C(C=C3)C(=O)C4=CC=CO4 |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/gw406108x.html |
| Additional Information | https://file.selleck.cn/downloads/struct/s6953-gw108x-chemical-structure.gif |