BMS-986142
BMS-986142 is a potent and highly selective reversible small molecule inhibitor of BTK with an IC50 of 0.5 nM. In a panel of 384 kinases, only five kinases were inhibited by BMS-986142 with less than 100-fold selectivity for BTK (TEC, ITK, BLK, TXK and BMX).
| Trivial name | N/A |
| Catalog Number | S8381 |
| Molecular Formula | C32H30F2N4O4 |
| CAS# | 1643368-58-4 |
| Inchi | InChI=1S/C32H30F2N4O4/c1-15-17(7-6-10-24(15)38-30(40)19-8-5-9-21(33)28(19)37(4)31(38)41)25-22(34)14-20(29(35)39)27-26(25)18-12-11-16(32(2,3)42)13-23(18)36-27/h5-10,14,16,36,42H,11-13H2,1-4H3,(H2,35,39 )/t16-/m0/s1 |
| Inchi Key | ZRYMMWAJAFUANM-INIZCTEOSA-N |
| SMILES | CC1=C(C=CC=C1N2C(=O)C3=C(C(=CC=C3)F)N(C2=O)C)C4=C(C=C(C5=C4C6=C(N5)CC(CC6)C(C)(C)O)C(=O)N)F |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/bms-986142.html |
| Additional Information | https://file.selleck.cn/downloads/struct/bms986142-chemical-structure-s8381.gif |