Glumetinib
Glumetinib is a potent and highly selective c-Met inhibitor with an IC50 of 0.42 ± 0.02 nmol/L. Glumetinib has greater than 2,400-fold selectivity for c-Met over those 312 kinases evaluated, including the c-Met family member RON and highly homologous kinases Axl, Mer, and TyrO3.
| Trivial name | SCC244 |
| Catalog Number | S8676 |
| Molecular Formula | C21H17N9O2S |
| CAS# | 1642581-63-2 |
| Inchi | InChI=1S/C21H17N9O2S/c1-27-11-16(7-24-27)14-3-4-20-23-10-21(29(20)13-14)33(31,32)30-19-5-15(6-22-18(19)9-26-30)17-8-25-28(2)12-17/h3-13H,1-2H3 |
| Inchi Key | RYBLECYFLJXEJX-UHFFFAOYSA-N |
| SMILES | CN1C=C(C=N1)C2=CN3C(=NC=C3S(=O)(=O)N4C5=C(C=N4)N=CC(=C5)C6=CN(N=C6)C)C=C2 |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/glumetinib.html |
| Additional Information | https://file.selleck.cn/downloads/struct/glumetinib-scc244-chemical-structure-s8676.gif |