Eltanexor (KPT-8602)
Eltanexor (KPT-8602, ONO-7706,ATG-016) is a second-generation, orally bioavailable XPO1 (also known as CRM1) inhibitor with IC50 values of 20−211 nM in 10 AML lines after 3 days exposure.
Trivial name | ONO-7706,ATG-016 |
Catalog Number | S8397 |
Molecular Formula | C17H10F6N6O |
CAS# | 1642300-52-4 |
Inchi | InChI=1S/C17H10F6N6O/c18-16(19,20)11-1-9(2-12(3-11)17(21,22)23)15-27-8-29(28-15)6-13(14(24)30)10-4-25-7-26-5-10/h1-8H,(H2,24,30)/b13-6+ |
Inchi Key | JFBAVWVBLRIWHM-AWNIVKPZSA-N |
SMILES | C1=C(C=C(C=C1C(F)(F)F)C(F)(F)F)C2=NN(C=N2)C=C(C3=CN=CN=C3)C(=O)N |
Size | 5mg |
Supplier Page | http://www.selleckchem.com/products/kpt-8602.html |
Additional Information | https://file.selleck.cn/downloads/struct/kpt-8602-chemical-structure-S8397.gif |