RAF709
RAF709 is a potent inhibitor of B/C RAF kinase with almost equivalent IC50 values of 0.4 nM for B-RAF and C-RAF, showing a high level of selectivity, demonstrating greater than 99% on-target binding to BRAF, BRAFV600E, and CRAF at 1 μM and very few off-targets with DDR1 (>99%), DDR2 (86%), FRK (92%), and PDGFRb (96%), the only kinases with binding >80% at 1 μM.
| Trivial name | N/A |
| Catalog Number | S8690 |
| Molecular Formula | C28H29F3N4O4 |
| CAS# | 1628838-42-5 |
| Inchi | InChI=1S/C28H29F3N4O4/c1-18-24(15-22(17-32-18)34-26(36)19-3-2-4-21(13-19)28(29,30)31)20-14-25(35-7-11-38-12-8-35)27(33-16-20)39-23-5-9-37-10-6-23/h2-4,13-17,23H,5-12H2,1H3,(H,34,36) |
| Inchi Key | FYNMINFUAIDIFL-UHFFFAOYSA-N |
| SMILES | CC1=C(C=C(C=N1)NC(=O)C2=CC(=CC=C2)C(F)(F)F)C3=CC(=C(N=C3)OC4CCOCC4)N5CCOCC5 |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/raf709.html |
| Additional Information | https://file.selleck.cn/downloads/struct/raf709-chemical-structure-s8690.gif |