PLX51107
PLX51107 is as a novel BET inhibitor with modest preference for bromodomain-1 (BD1) versus bromodomain-2 (BD2) within each BET protein (Kd = 1.6, 2.1, 1.7, and 5 nM for BD1 and 5.9, 6.2, 6.1 and 120 nM for BD2 of BRD2, BRD3, BRD4, and BRDT, respectively. Among non-BET proteins, PLX51107 shows significant interactions only with the bromodomains of CBP and EP300 (p300) (Kd in the 100 nM range).
| Trivial name | N/A |
| Catalog Number | S8739 |
| Molecular Formula | C26H22N4O3 |
| CAS# | 1627929-55-8 |
| Inchi | InChI=1S/C26H22N4O3/c1-15-24(17(3)33-29-15)20-12-23-25(28-13-20)21(18-7-9-19(10-8-18)26(31)32)14-30(23)16(2)22-6-4-5-11-27-22/h4-14,16H,1-3H3,(H,31,32)/t16-/m0/s1 |
| Inchi Key | AMSUHYUVOVCWTP-INIZCTEOSA-N |
| SMILES | CC1=C(C(=NO1)C)C2=CC3=C(C(=CN3C(C)C4=CC=CC=N4)C5=CC=C(C=C5)C(=O)O)N=C2 |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/plx51107.html |
| Additional Information | https://file.selleck.cn/downloads/struct/plx51107-chemical-structure-s8739.gif |