GSK3179106
GSK3179106 is a potent, selective, and gut-restricted pyridone hinge binder small molecule RET (c-RET) kinase inhibitor with a RET IC50 of 0.3 nM and is efficacious in vivo.
| Trivial name | N/A |
| Catalog Number | S8821 |
| Molecular Formula | C22H21F4N3O4 |
| CAS# | 1627856-64-7 |
| Inchi | InChI=1S/C22H21F4N3O4/c1-4-32-16-9-19(30)27-11-14(16)12-5-6-13(15(23)7-12)8-20(31)28-18-10-17(33-29-18)21(2,3)22(24,25)26/h5-7,9-11H,4,8H2,1-3H3,(H,27,30)(H,28,29,31) |
| Inchi Key | IDXKJSSOUXWLDB-UHFFFAOYSA-N |
| SMILES | CCOC1=CC(=O)NC=C1C2=CC(=C(C=C2)CC(=O)NC3=NOC(=C3)C(C)(C)C(F)(F)F)F |
| Size | 2mg |
| Supplier Page | http://www.selleckchem.com/products/gsk3179106.html |
| Additional Information | https://file.selleck.cn/downloads/struct/gsk3179106-chemical-structure-s8821.gif |