PFI-2
PFI-2 ((R)-PFI-2 hydrochloride) hydrochloride is a potent and selective SET domain containing lysine methyltransferase 7 (SETD7) inhibitor. (R)-PFI-2 shows high inhibiting activity with IC50 value of 2.0 nM and (S)-PFI-2 shows inhibiting activity with IC50 value of 1.0 μM. PFI-2 hydrochloride can be used for the research of chronic kidney disease and inflammation response in the development of renal fibrosis.
| Trivial name | (R)-PFI-2 |
| Catalog Number | E7474 |
| Molecular Formula | C16H13Cl3N2OS |
| CAS# | 1627676-59-8 |
| Inchi | InChI=1S/C16H13Cl3N2OS/c17-12-1-2-13(14(18)7-12)15(8-21-5-4-20-10-21)22-9-11-3-6-23-16(11)19/h1-7,10,15H,8-9H2 |
| Inchi Key | QXHHHPZILQDDPS-UHFFFAOYSA-N |
| SMILES | C1=CC(=C(C=C1Cl)Cl)C(CN2C=CN=C2)OCC3=C(SC=C3)Cl |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/pfi-2-e7474.html |
| Additional Information | https://file.selleck.cn/downloads/struct/e7474-pfi-2-chemical-structure-tube.png |