Lirametostat (CPI-1205)
Lirametostat (CPI-1205) is an orally available selective inhibitor of the histone lysine methyltransferase EZH2 with IC50 values of 2 nM and 52 nM for EZH2 and EZH1 respectively. It has potential antineoplastic activity.
Trivial name | CPI 1205, CPI1205 |
Catalog Number | S8353 |
Molecular Formula | C27H33F3N4O3 |
CAS# | 1621862-70-1 |
Inchi | InChI=1S/C27H33F3N4O3/c1-16-13-23(37-4)21(25(35)32-16)14-31-26(36)24-18(3)34(22-8-6-5-7-20(22)24)17(2)19-9-11-33(12-10-19)15-27(28,29)30/h5-8,13,17,19H,9-12,14-15H2,1-4H3,(H,31,36)(H,32,35)/t17-/m1/s1 |
Inchi Key | HPODOLXTMDHLLC-QGZVFWFLSA-N |
SMILES | CC1=CC(=C(C(=O)N1)CNC(=O)C2=C(N(C3=CC=CC=C32)C(C)C4CCN(CC4)CC(F)(F)F)C)OC |
Size | 10mM/1mL |
Supplier Page | http://www.selleckchem.com/products/cpi-1205.html |
Additional Information | https://file.selleck.cn/downloads/struct/cpi-1205-chemical-structure-s8353.gif |