Amezalpat
Amezalpat is a first-in-class, oral, competitive antagonist of peroxisome proliferator-activated receptor α (PPARα), with IC50 of 0.04 µM. It inhibits fatty acid oxidation (FAO), disrupting cancer cell metabolism and restoring immune responses, and shows antitumor activity in research on advanced solid tumors.
| Trivial name | TPST-1120 |
| Catalog Number | E8300 |
| Molecular Formula | C8H9ClN2O2S |
| CAS# | 1616372-41-8 |
| Inchi | InChI=1S/C8H9ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-5,10-11H,1H3 |
| Inchi Key | VZRNTCHTJRLTMU-UHFFFAOYSA-N |
| SMILES | CC1NC2=C(C=C(C=C2)Cl)S(=O)(=O)N1 |
| Size | 1mg |
| Supplier Page | http://www.selleckchem.com/products/amezalpat.html |
| Additional Information | https://file.selleck.cn/downloads/struct/e8300-amezalpat-chemical-structure-tube.png |