Unesbulin (PTC596)

Unesbulin (PTC596) is a second-generation BMI-1 inhibitor that accelerates BMI-1 degradation. PTC596 downregulates MCL-1 and induces p53-independent mitochondrial apoptosis. IC50 values at 72 hours ranged from 68 to 340 nM in mantle cell lymphoma (MCL) cell lines.

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Trivial name	N/A
Catalog Number	S8820
Molecular Formula	C19H13F5N6
CAS#	1610964-64-1
Inchi	InChI=1S/C19H13F5N6/c1-9-26-13-7-4-11(20)8-14(13)30(9)18-28-16(25)15(21)17(29-18)27-12-5-2-10(3-6-12)19(22,23)24/h2-8H,1H3,(H3,25,27,28,29)
Inchi Key	TWLWOOPCEXYVBE-UHFFFAOYSA-N
SMILES	CC1=NC2=C(N1C3=NC(=C(C(=N3)NC4=CC=C(C=C4)C(F)(F)F)F)N)C=C(C=C2)F
Size	5mg
Supplier Page	http://www.selleckchem.com/products/ptc596.html
Additional Information	https://file.selleck.cn/downloads/struct/ptc596-chemical-structure-s8820.gif