(E/Z)-BCI
(E/Z)-BCI (BCI, NSC 150117) is an inhibitor of dual specific phosphatase 1/6 (DUSP1/DUSP6) and mitogen-activated protein kinase with EC50 of 13.3 μM and 8.0 μM for DUSP6 and DUSP1 in cells, respectively. (E)-BCI induces apoptosis via generation of reactive oxygen species (ROS) and activation of intrinsic mitochondrial pathway in H1299 lung cancer cells.
| Trivial name | BCI, NSC 150117 |
| Catalog Number | S0056 |
| Molecular Formula | C22H23NO |
| CAS# | 15982-84-0 |
| SMILES | C1CCC(CC1)NC2C3=CC=CC=C3C(=O)C2=CC4=CC=CC=C4 |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/dual-specificity-protein-phosphatase-1-6-Inhibitor-bcl.html |
| Additional Information | https://file.selleck.cn/downloads/struct/s0056-dual-specificity-protein-phosphatase-1-6-inhibitor-chemical-structure.gif |