LE135
LE135 is a potent RAR antagonist that binds selectively to RARα (Ki of 1.4 μM) and RARβ (Ki of 220 nM), and has a higher affinity to RARβ. LE135 is highly selective over RARγ, RXRα, RXRβ and RXRγ. LE135 is also a potent TRPV1 and TRPA1 receptors activator with EC50s of 2.5 μM and 20 μM, respectively.
| Catalog Number | E7685 |
| Molecular Formula | C22H29N3O4S |
| CAS# | 155877-83-1 |
| Inchi | InChI=1S/C22H29N3O4S/c26-21(18-30(27)17-20-7-6-14-28-20)23-9-2-5-13-29-22-15-19(8-10-24-22)16-25-11-3-1-4-12-25/h2,5-8,10,14-15H,1,3-4,9,11-13,16-18H2,(H,23,26)/b5-2- |
| Inchi Key | KMZQAVXSMUKBPD-DJWKRKHSSA-N |
| SMILES | C1CCN(CC1)CC2=CC(=NC=C2)OCC=CCNC(=O)CS(=O)CC3=CC=CO3 |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/le135.html |
| Additional Information | https://file.selleck.cn/downloads/struct/e7685-le135-chemical-structure-tube.png |