LY294002
LY294002 (SF 1101, NSC 697286) is the first synthetic molecule known to inhibit PI3Kα/δ/β with IC50 of 0.5 μM/0.57 μM/0.97 μM, respectively; more stable in solution than Wortmannin, and also blocks autophagosome formation. It not only binds to class I PI3Ks and other PI3K-related kinases, but also to novel targets seemingly unrelated to the PI3K family. LY294002 also inhibits CK2 with IC50 of 98 nM. LY294002 is a non-specific DNA-PKcs inhibitor and activates autophagy and apoptosis.
| Trivial name | SF 1101, NSC 697286 |
| Catalog Number | S1105 |
| Molecular Formula | C19H17NO3 |
| CAS# | 154447-36-6 |
| Inchi | InChI=1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2 |
| Inchi Key | CZQHHVNHHHRRDU-UHFFFAOYSA-N |
| SMILES | C1COCCN1C2=CC(=O)C3=C(O2)C(=CC=C3)C4=CC=CC=C4 |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/LY294002.html |
| Additional Information | https://file.selleck.cn/downloads/struct/LY294002-chemical-structure-S1105.gif |