Thioguanine
Thioguanine, a purine antimetabolite, inhibits DNMT1 activity through ubiquitin-targeted degradation, used in the treatment of acute lymphoblastic leukemia, autoimmune disorders (e.g., Crohn’s disease, rheumatoid arthritis) and organ transplant recipients.
| Trivial name | NSC 752, 6-Thioguanine, 2-Amino-6-purinethiol |
| Catalog Number | S1774 |
| Molecular Formula | C18H16N2O2 |
| CAS# | 154-42-7 |
| Inchi | InChI=1S/C18H16N2O2/c1-12-7-8-15-14(11-12)16(21)18(22)9-10-20(17(18)19-15)13-5-3-2-4-6-13/h2-8,11,22H,9-10H2,1H3/t18-/m1/s1 |
| Inchi Key | LZAXPYOBKSJSEX-GOSISDBHSA-N |
| SMILES | CC1=CC2=C(C=C1)N=C3C(C2=O)(CCN3C4=CC=CC=C4)O |
| Size | 50mg |
| Supplier Page | http://www.selleckchem.com/products/Thioguanine.html |
| Additional Information | https://file.selleck.cn/downloads/struct/Thioguanine-chemical-structure-S1774.gif |