AG-1478
AG-1478 is a selective EGFR inhibitor with IC50 of 3 nM in cell-free assays, almost no activity on HER2-Neu, PDGFR, Trk, Bcr-Abl and InsR. AG-1478 (Tyrphostin AG-1478) inhibits encephalomyocarditis virus (EMCV) and hepatitis c virus (HCV) by targeting phosphatidylinositol 4-kinase IIIα (PI4KA).
| Trivial name | Tyrphostin AG-1478, NSC 693255 |
| Catalog Number | S2728 |
| Molecular Formula | C16H14ClN3O2 |
| CAS# | 153436-53-4,175178-82-2 |
| Inchi | InChI=1S/C16H14ClN3O2/c1-21-14-7-12-13(8-15(14)22-2)18-9-19-16(12)20-11-5-3-4-10(17)6-11/h3-9H,1-2H3,(H,18,19,20) |
| Inchi Key | GFNNBHLJANVSQV-UHFFFAOYSA-N |
| SMILES | COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=CC=C3)Cl)OC |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/ag-1478-tyrphostin-ag-1478.html |
| Additional Information | https://file.selleck.cn/downloads/struct/ag-1478-tyrphostin-ag-1478-chemical-structure-s2728.gif |