Nolatrexed dihydrochloride
Nolatrexed dihydrochloride (AG 337) is a non-competitive lipophilic inhibitor of thymidylate synthase, interacts at the folate cofactor binding site of the enzyme, with a Ki of 11 nM for human thymidylate synthase. Nolatrexed dihydrochloride (AG 337) induces cell cycle arrest in S phase of cancer cells. Anti-cancer activity.
| Trivial name | AG 337 |
| Catalog Number | E7302 |
| Molecular Formula | C19H27NO3 |
| CAS# | 152946-68-4 |
| Inchi | InChI=1S/C19H27NO3/c1-12(2)7-14-11-20-6-5-13-8-18(22-3)19(23-4)9-15(13)16(20)10-17(14)21/h8-9,12,14,16H,5-7,10-11H2,1-4H3 |
| Inchi Key | MKJIEFSOBYUXJB-UHFFFAOYSA-N |
| SMILES | CC(C)CC1CN2CCC3=CC(=C(C=C3C2CC1=O)OC)OC |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/nolatrexed-dihydrochloride.html |
| Additional Information | https://file.selleck.cn/downloads/struct/e7302-nolatrexed-dihydrochloride-chemical-structure-tube.png |