Adezmapimod (SB203580)
Adezmapimod (SB203580, RWJ 64809, PB 203580) is a p38 MAPK inhibitor with IC50 of 0.3-0.5 μM in THP-1 cells, 10-fold less sensitive to SAPK3(106T) and SAPK4(106T) and blocks PKB phosphorylation with IC50 of 3-5 μM. SB203580 induces mitophagy and autophagy.
| Trivial name | RWJ 64809, PB 203580 |
| Catalog Number | S1076 |
| Molecular Formula | C21H16FN3OS |
| CAS# | 152121-47-6 |
| Inchi | InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25) |
| Inchi Key | CDMGBJANTYXAIV-UHFFFAOYSA-N |
| SMILES | CS(=O)C1=CC=C(C=C1)C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F |
| Size | 1g |
| Supplier Page | http://www.selleckchem.com/products/SB-203580.html |
| Additional Information | https://file.selleck.cn/downloads/struct/SB-203580-chemical-structure-S1076.gif |