SB202190
SB202190 is a potent p38 MAPK inhibitor targeting p38α/β with IC50 of 50 nM/100 nM in cell-free assays, sometimes used instead of SB 203580 to investigate potential roles for SAPK2a/p38 in vivo. SB202190 inhibits endothelial cell apoptosis via induction of autophagy and heme oxygenase-1. SB202190 significantly suppresses Erastin‐dependent ferroptosis.
| Trivial name | FHPI |
| Catalog Number | S1077 |
| Molecular Formula | C20H14N3OF |
| CAS# | 152121-30-7 |
| Inchi | InChI=1S/C20H14FN3O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15/h1-12,25H,(H,23,24) |
| Inchi Key | QHKYPYXTTXKZST-UHFFFAOYSA-N |
| SMILES | C1=CC(=CC=C1C2=NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F)O |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/SB-202190.html |
| Additional Information | https://file.selleck.cn/downloads/struct/SB-202190-chemical-structure-S1077.gif |