Taletrectinib (DS-6051b)
Taletrectinib (DS-6051b, AB-106) is a new-generation selective ROS1/NTRK inhibitor with ic50 of 0.207 nM,0.622 nM,2.28 nM and 0.980 nM for ROS1,NTRK1,NTRK2 and NTRK3,respectively.
Trivial name | AB-106 |
Catalog Number | S8901 |
Molecular Formula | C29H34FN5O5 |
CAS# | 1505515-69-4 |
Inchi | InChI=1S/C23H24FN5O.C6H10O4/c1-15(25)14-30-20-8-6-17(7-9-20)21-13-26-23-11-10-22(28-29(21)23)27-16(2)18-4-3-5-19(24)12-18;7-5(8)3-1-2-4-6(9)10/h3-13,15-16H,14,25H2,1-2H3,(H,27,28);1-4H2,(H,7,8)(H,9,10 )/t15-,16-;/m1./s1 |
Inchi Key | DORJQZDOULKINH-QNBGGDODSA-N |
SMILES | CC(COC1=CC=C(C=C1)C2=CN=C3N2N=C(C=C3)NC(C)C4=CC(=CC=C4)F)N.C(CCC(=O)O)CC(=O)O |
Size | 5mg |
Supplier Page | http://www.selleckchem.com/products/ds-6051b.html |
Additional Information | https://file.selleck.cn/downloads/struct/ds-6051b-chemical-structure-s8901.gif |