Pemetrexed disodium
Pemetrexed disodium is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. Pemetrexed induces autophagy and apoptosis.
Trivial name | LY-231514 disodium |
Catalog Number | S1135 |
Molecular Formula | C20H19N5Na2O6 |
CAS# | 150399-23-8 |
Inchi | InChI=1S/C20H21N5O6.2Na/c21-20-24-16-15(18(29)25-20)12(9-22-16)6-3-10-1-4-11(5-2-10)17(28)23-13(19(30)31)7-8-14(26)27;;/h1-2,4-5,9,13H,3,6-8H2,(H,23,28)(H,26,27)(H,30,31)(H4,21,22,24,25,29);;/q;2*+1/p -2/t13-;;/m0../s1 |
Inchi Key | NYDXNILOWQXUOF-GXKRWWSZSA-L |
SMILES | C1=CC(=CC=C1CCC2=CNC3=C2C(=O)NC(=N3)N)C(=O)NC(CCC(=O)[O-])C(=O)[O-].[Na+].[Na+] |
Size | 200mg |
Supplier Page | http://www.selleckchem.com/products/Pemetrexed-disodium.html |
Additional Information | https://file.selleck.cn/downloads/struct/Pemetrexed-Alimta-chemical-structure-S1135.gif |