Sacubitril
Sacubitril is a potent and orally active inhibitor of NEP (neprilysin) with an IC50 of 5 nM. It exhibits the potential to treat chronic heart failure with reduced ejection fraction.
| Trivial name | AHU-377 |
| Catalog Number | E7186 |
| Molecular Formula | C21H27N5O4S |
| CAS# | 149709-62-6 |
| Inchi | InChI=1S/C21H27N5O4S/c1-15-13-24-19(14-23-15)20(27)22-12-11-16-7-9-18(10-8-16)31(29,30)26-21(28)25-17-5-3-2-4-6-17/h7-10,13-14,17H,2-6,11-12H2,1H3,(H,22,27)(H2,25,26,28) |
| Inchi Key | ZJJXGWJIGJFDTL-UHFFFAOYSA-N |
| SMILES | CC1=CN=C(C=N1)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCCCC3 |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/sacubitril.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E7186-Sacubitril-chemical-structure.png |