Tiron is a non-toxic chelator of a variety of metals. Tiron is cell permeable analog of vitamin E and function as hydroxyl radical and superoxide scavenger. Tiron is an orally active antioxidant. Tiron can be used to alleviate acute metal overload in animals[2].In Vitro:Tiron (10 mM) protects Chinese hamster V79 cells against H2O2-induced cytotoxicity.
Tiron (0-20 mM) protects supercoiled DNA from metal-mediated superoxide-dependent strand breaks.
Tiron (50 nM-200 nM, 48 h) inhibits HG-induced neonatal rat cardiomyocytes apoptosis.
Tiron (50 nM-200 nM, 48 h) reduces intracellular osteopontin in neonatal rat cardiomyocytes.
Tiron (0.2 mM, 2 h) inhibits UVB-induced up-regulation of MMP-1 and MMP-3 in HDFs.
Tiron (0.7 mM, 48 h) increases the percentage of PT4 cells in both the S and G2/M phases.
In Vivo:Tiron (200 mg/kg, oral gavage) ameliorates oxidative stress and inflammation in a murine model of airway remodeling[2].
Tiron (300 mg/kg, i.p., daily for two weeks) alleviated apoptosis of the left ventricular cardiomyocytes in STZ-induced diabetic mice.