Flavopiridol (Alvocidib)

Flavopiridol (Alvocidib) competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4, CDK6, and CDK9 with IC50 values in the 20-100 nM range. It is more selective for CDK1, 2, 4, 6, 9 versus CDK7. Flavopiridol is initially found to inhibit EGFR and PKA. Flavopiridol induces autophagy and ER stress. Flavopiridol blocks HIV-1 replication. Phase 1/2.

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Trivial name	NSC 649890, HMR-1275, L86-8275
Catalog Number	S1230
Molecular Formula	C21H20ClNO5
CAS#	146426-40-6
Inchi	InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12-,17+/m0/s1
Inchi Key	BIIVYFLTOXDAOV-YVEFUNNKSA-N
SMILES	CN1CCC(C(C1)O)C2=C(C=C(C3=C2OC(=CC3=O)C4=CC=CC=C4Cl)O)O
Size	5mg
Supplier Page	http://www.selleckchem.com/products/Flavopiridol.html
Additional Information	https://file.selleck.cn/downloads/struct/flavopiridol-chemical-structure-s1230.gif