Flavopiridol (Alvocidib)

Flavopiridol (Alvocidib) competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4, CDK6, and CDK9 with IC50 values in the 20-100 nM range. It is more selective for CDK1, 2, 4, 6, 9 versus CDK7. Flavopiridol is initially found to inhibit EGFR and PKA. Flavopiridol induces autophagy and ER stress. Flavopiridol blocks HIV-1 replication. Phase 1/2.

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Trivial name	NSC 649890, HMR-1275, L86-8275
Catalog Number	S1230
Molecular Formula	C30H32ClN7O2
CAS#	146426-40-6
Inchi	InChI=1S/C30H32ClN7O2/c1-37(2)15-6-10-27(39)34-21-13-11-20(12-14-21)29(40)38-16-5-7-22(19-38)35-30-33-18-25(31)28(36-30)24-17-32-26-9-4-3-8-23(24)26/h3-4,6,8-14,17-18,22,32H,5,7,15-16,19H2,1-2H3,(H,34 ,39)(H,33,35,36)/b10-6+/t22-/m1/s1
Inchi Key	RUBYHLPRZRMTJO-MOVYNIQHSA-N
SMILES	CN(C)CC=CC(=O)NC1=CC=C(C=C1)C(=O)N2CCCC(C2)NC3=NC=C(C(=N3)C4=CNC5=CC=CC=C54)Cl
Size	5mg
Supplier Page	http://www.selleckchem.com/products/Flavopiridol.html
Additional Information	https://file.selleck.cn/downloads/struct/flavopiridol-chemical-structure-s1230.gif