5-HT7R antagonist 2 | MedChemExpress (MCE)

5-HT7R antagonist 2 (compound 4h) is a 5-HT7R antagonist that antagonizes the G protein and β-arrestin signaling pathways, with a Ki of 67 nM, the IC50 values in cAMP and Tango tests were 2.59 μM and 39.57 μM, respectively. 5-HT7R antagonist 2 has an effect on neurogenesis and can reduce repetitive behaviors related to autism spectrum disorder (ASD) and restore neurogenesis of ASD impairment[1].
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Pharmacokinetic Analysis ICR Male Mice[1]
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药代动力学分析[1]
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Plasma Intravenous Administration Intraperitoneal Administration
Tmax (h) 0.08 0.25
T1/2 (h) 0.77 1.06
Cmax (ng/mL) 33.07 156.44
AUClast (ng·h/mL) 28.31 143.27
CL (L/h/kg) 41.61 –
Vss (L/kg) 32.43 –
MRT (h) 0.79 0.93
F (%) 50.60
Trivial name 5-HT7R antagonist 2
Catalog Number HY-163345
Research Area Neurological Disease
CAS# 1448808-50-1
Purity ≥98.0%
SMILES COC1=C(C2=CC=CC(C3=NCCN3)=C2)C=CC=C1
Size 1 mg
Supplier Page https://www.medchemexpress.com/5-ht7r-antagonist-2.html