S55746
S55746 (S 055746,BCL201) is a novel, orally active BCL-2 specific inhibitor (Ki = 1.3 nM) with poor affinity for BCL-XL and no significant binding to MCL-1, BFL-1 (BCL2A1/A1). The selectivity of S55746 for BCL-2 versus BCL-XL ranges from ~70 to 400 folds.
| Trivial name | S 055746,BCL201 |
| Catalog Number | S8759 |
| Molecular Formula | C43H42N4O6 |
| CAS# | 1448584-12-0 |
| Inchi | InChI=1S/C43H42N4O6/c48-34-15-13-32(14-16-34)47(31-10-2-1-3-11-31)43(50)37-23-39(45-17-7-6-12-38(37)45)35-24-40-41(53-28-52-40)25-36(35)42(49)46-26-30-9-5-4-8-29(30)22-33(46)27-44-18-20-51-21-19-44/h1 -5,8-11,13-16,23-25,33,48H,6-7,12,17-22,26-28H2/t33-/m0/s1 |
| Inchi Key | VYXJULKGMXJVGI-XIFFEERXSA-N |
| SMILES | C1CCN2C(=C(C=C2C3=CC4=C(C=C3C(=O)N5CC6=CC=CC=C6CC5CN7CCOCC7)OCO4)C(=O)N(C8=CC=CC=C8)C9=CC=C(C=C9)O)C1 |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/s55746-s055746-bcl201.html |
| Additional Information | https://file.selleck.cn/downloads/struct/s55746-s-055746-bcl201-chemical-structure-s8759.gif |