VH032

VH032 is a potent and selective VHL ligand used in PROTACs that binds to the VHL E3 ligase with a Kd of 185 nM and disrupts the VHL:HIF-α interaction. By stabilizing HIF-α, it activates the hypoxic response and serves as a tool for developing therapies targeting hypoxia signaling.

Price Not Available 5mg VH032 Supplier Page
Catalog Number E7619
Molecular Formula C19H24N2O4.1/2C4H4O4
CAS# 1448188-62-2
Inchi InChI=1S/2C19H24N2O4.C4H4O4/c2*1-13(9-14-3-6-16(25-2)7-4-14)20-11-19(24)15-5-8-18(23)17(10-15)21-12-22;5-3(6)1-2-4(7)8/h2*3-8,10,12-13,19-20,23-24H,9,11H2,1-2H3,(H,21,22);1-2H,(H,5,6)(H,7,8)/b;;2-1+/t 2*13-,19+;/m00./s1
Inchi Key OBRNDARFFFHCGE-PERKLWIXSA-N
SMILES CC(CC1=CC=C(C=C1)OC)NCC(C2=CC(=C(C=C2)O)NC=O)O.CC(CC1=CC=C(C=C1)OC)NCC(C2=CC(=C(C=C2)O)NC=O)O.C(=CC(=O)O)C(=O)O
Size 5mg
Supplier Page http://www.selleckchem.com/products/vh032.html
Additional Information https://file.selleck.cn/downloads/struct/E7619-VH032-chemical-structure.png