Lifirafenib (BGB-283)

Lifirafenib (BGB-283, Beigene-283) potently inhibits RAF family kinases and EGFR activities in biochemical assays with IC50 values of 23, 29 and 495 nM for the recombinant BRAFV600E kinase domain, EGFR and EGFR T790M/L858R mutant.

Price Not Available 5mg Lifirafenib (BGB-283) Supplier Page

Trivial name	Beigene-283
Catalog Number	S7926
Molecular Formula	C25H17F3N4O3
CAS#	1446090-79-4
Inchi	InChI=1S/C25H17F3N4O3/c26-25(27,28)11-1-4-15-16(9-11)31-24(30-15)21-20-14-10-12(2-5-17(14)35-22(20)21)34-18-7-8-29-23-13(18)3-6-19(33)32-23/h1-2,4-5,7-10,20-22H,3,6H2,(H,30,31)(H,29,32,33)/t20-,21-,22 -/m0/s1
Inchi Key	NGFFVZQXSRKHBM-FKBYEOEOSA-N
SMILES	C1CC(=O)NC2=NC=CC(=C21)OC3=CC4=C(C=C3)OC5C4C5C6=NC7=C(N6)C=C(C=C7)C(F)(F)F
Size	5mg
Supplier Page	http://www.selleckchem.com/products/bgb-283-bgb283.html
Additional Information	https://file.selleck.cn/downloads/struct/bgb-283-bgb283-chemical-structure-s7926.gif