Ripretinib
Ripretinib is an orally bioavailable switch pocket control inhibitor of wild-type and mutated forms of the tumor-associated antigens (TAA) mast/stem cell factor receptor (SCFR) Kit (c-Kit) and PDGFR-alpha, with IC50 values of 4 nM, 8 nM, 18 nM, 5 nM and 14 nM for WT Kit (c-Kit), V654A Kit (c-Kit), T670I Kit (c-Kit), D816H Kit (c-Kit) and D816V Kit (c-Kit), respectively.
| Trivial name | DCC-2618 |
| Catalog Number | S8757 |
| Molecular Formula | C24H21BrFN5O2 |
| CAS# | 1442472-39-0 |
| Inchi | InChI=1S/C24H21BrFN5O2/c1-3-31-21-12-22(27-2)28-13-14(21)9-17(23(31)32)16-10-20(19(26)11-18(16)25)30-24(33)29-15-7-5-4-6-8-15/h4-13H,3H2,1-2H3,(H,27,28)(H2,29,30,33) |
| Inchi Key | CEFJVGZHQAGLHS-UHFFFAOYSA-N |
| SMILES | CCN1C2=CC(=NC=C2C=C(C1=O)C3=CC(=C(C=C3Br)F)NC(=O)NC4=CC=CC=C4)NC |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/ripretinib-dcc-2618.html |
| Additional Information | https://file.selleck.cn/downloads/struct/dcc-2618-chemical-structure-s8757.gif |