2′,3′-cGAMP
2′,3′-cGAMP (2′-3′-cyclic GMP-AMP) is an endogenous cyclic GMP-AMP produced in mammalian cells in response to cytoplasmic DNA. It binds STING with high affinity Kd of 3.79 nM and is a potent inducer of interferon-β (IFNβ).
| Trivial name | 2'-3'-cyclic GMP-AMP |
| Catalog Number | E5781 |
| Molecular Formula | C20H17ClF4N4O4S |
| CAS# | 1441190-66-4 |
| Inchi | InChI=1S/C20H17ClF4N4O4S/c21-14-3-5-15(6-4-14)34(31,32)29(17(18(26)30)7-8-20(23,24)25)10-13-2-1-12(9-16(13)22)19-27-11-33-28-19/h1-6,9,11,17H,7-8,10H2,(H2,26,30)/t17-/m1/s1 |
| Inchi Key | XEAOPVUAMONVLA-QGZVFWFLSA-N |
| SMILES | C1=CC(=CC=C1S(=O)(=O)N(CC2=C(C=C(C=C2)C3=NOC=N3)F)C(CCC(F)(F)F)C(=O)N)Cl |
| Size | 1mg |
| Supplier Page | http://www.selleckchem.com/products/2-3-cgamp-e5781.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E5781-2-3-cGAMP-chemical-structure.png |