SAR131675
SAR131675 is a VEGFR3 inhibitor with IC50/Ki of 23 nM/12 nM in cell-free assays, about 50- and 10-fold more selective for VEGFR3 than VEGFR1/2, little activity against Akt1, CDKs, PLK1, EGFR, IGF-1R, c-Met, Flt2 etc.
| Trivial name | N/A |
| Catalog Number | S2842 |
| Molecular Formula | C22H22F3N3O3S2 |
| CAS# | 1433953-83-3 |
| Inchi | InChI=1S/C22H22F3N3O3S2/c1-2-28-12-17(13-4-3-5-14(10-13)22(23,24)25)19-16(21(28)29)11-18(32-19)20(26)27-15-6-8-33(30,31)9-7-15/h3-5,10-12,15H,2,6-9H2,1H3,(H2,26,27) |
| Inchi Key | WRUWGLUCNBMGPS-UHFFFAOYSA-N |
| SMILES | CCN1C=C(C2=C(C1=O)C=C(S2)C(=NC3CCS(=O)(=O)CC3)N)C4=CC(=CC=C4)C(F)(F)F |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/sar131675.html |
| Additional Information | https://file.selleck.cn/downloads/struct/SAR131675-chemical-structure-s2842.gif |