SAR131675
SAR131675 is a VEGFR3 inhibitor with IC50/Ki of 23 nM/12 nM in cell-free assays, about 50- and 10-fold more selective for VEGFR3 than VEGFR1/2, little activity against Akt1, CDKs, PLK1, EGFR, IGF-1R, c-Met, Flt2 etc.
| Trivial name | N/A |
| Catalog Number | S2842 |
| Molecular Formula | C18H22N4O4 |
| CAS# | 1433953-83-3 |
| Inchi | InChI=1S/C18H22N4O4/c1-5-22-15(19)13(17(24)20-3)14(23)12-7-6-11(21-16(12)22)8-9-18(2,25)10-26-4/h6-7,25H,5,10,19H2,1-4H3,(H,20,24)/t18-/m1/s1 |
| Inchi Key | PFMPOBVAYMTUOX-GOSISDBHSA-N |
| SMILES | CCN1C(=C(C(=O)C2=C1N=C(C=C2)C#CC(C)(COC)O)C(=O)NC)N |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/sar131675.html |
| Additional Information | https://file.selleck.cn/downloads/struct/SAR131675-chemical-structure-s2842.gif |