(1R)-IDH889 | MedChemExpress (MCE)
(1R)-IDH889 is the inactive isomer of IDH889 (HY-112289), and can be used as an experimental control. IDH889 is an orally available, brain penetrant, allosteric and mutant specific inhibitor of isocitrate dehydrogenase 1 (IDH1). IDH889 has potent selectivity for IDH1 R132* mutations, with IC50s of 0.02 μM, 0.072 μM and 1.38 μM for IDH1R132H, IDH1R132C and IDH1wt, respectively. IDH889 shows potent cellular inhibition of R-2-hydroxyglutarate (2-HG) production with an IC50 of 0.014 μM[1].
Trivial name | (1R)-IDH889 |
Catalog Number | HY-112289B |
Research Area | Cancer |
CAS# | 1429179-08-7 |
Purity | ≥98.00% |
SMILES | O=C1OC[C@H](C(C)C)N1C2=NC(N[C@@H](C3=NC=C(C4=CC=C(F)C(C)=C4)C=N3)C)=NC=C2 |
PubChem Chemical Structure ID | 89479416 |
Size | 25 mg |
Supplier Page | https://www.medchemexpress.com/1r-idh889.html |