Usmarapride (free base)| ChemScene
Usmarapride (SUVN-D4010) free base is a potent, selective, orally active and brain penetrant 5-HT4 receptor partial agonist (EC50=44 nM). Usmarapride (SUVN-D4010) free base can be used for the research of cognitive deficits associated with Alzheimer’s disease.In Vivo: Usmarapride (SUVN-D4010) (1-3 mg/kg; p.o.; Male Wistar rats 10-12 weeks old) free base attenuates the long-term memory deficits in object recognition test (ORT).
Usmarapride (1, 3, and 10 mg/kg; p.o.) free base significantly reverses the scopolamine-induced amnesia.
Usmarapride free base shows a statistically significant effect at 3.0 mg/kg on both exploration time and recognition index.
Usmarapride (SUVN-D4010) free base shows good oral exposures, good bioavailability, and good brain exposures in rats.
Trivial name | Usmarapride (free base) |
Catalog Number | CS-0254147 |
Alternative Name(s) | SUVN-D4010 (free base) |
Molecular Formula | 383.49 |
CAS# | 1428862-32-1 |
Purity | >98% |
Condensed Formula | C21H29N5O2 |
Size | 100mg |
Supplier Page | www.chemscene.com/1428862-32-1.html |