5-(N,N-Hexamethylene)-amiloride

5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride; HMA) is a potent inhibitor of the Na⁺/H⁺ exchanger, lowering intracellular pH and inducing apoptosis. It also inhibits the HIV-1 Vpu virus ion channel and suppresses replication of mouse hepatitis virus (MHV) and human coronavirus 229E (HCoV-229E) in cultured L929 cells, with EC₅₀ values of 3.91 μM and 1.34 μM, respectively.

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Trivial name	Hexamethylene amiloride, HMA
Catalog Number	E7765
Molecular Formula	C31H48O2S2
CAS#	1428-95-1
Inchi	InChI=1S/C31H48O2S2/c1-27(2,3)21-15-19(16-22(25(21)32)28(4,5)6)34-31(13,14)35-20-17-23(29(7,8)9)26(33)24(18-20)30(10,11)12/h15-18,32-33H,1-14H3
Inchi Key	FYPMFJGVHOHGLL-UHFFFAOYSA-N
SMILES	CC(C)(C)C1=CC(=CC(=C1O)C(C)(C)C)SC(C)(C)SC2=CC(=C(C(=C2)C(C)(C)C)O)C(C)(C)C
Size	5mg
Supplier Page	http://www.selleckchem.com/products/5-n-n-hexamethylene-amiloride.html
Additional Information	https://file.selleck.cn/downloads/struct/E7765-5-N-N-Hexamethylene-amiloride-chemical-structure.png