Isosilybin A
Isosilybin A is a flavonolignan isolated from silymarin that exhibits anti-prostate cancer (PCA) efficacy with an IC50 of 32 μM in DU145 cells. It induces growth inhibition, G1 arrest, and apoptosis in PCA cells by targeting the Akt-NF-κB-AR axis, highlighting its potential as a therapeutic agent in clinical prostate cancer (PCA) management.
Catalog Number | E7972 |
Molecular Formula | C22H18FN7O |
CAS# | 142796-21-2 |
Inchi | InChI=1S/C22H18FN7O/c1-2-15(28-20-18-19(25-11-24-18)26-12-27-20)21-29-16-10-6-9-14(23)17(16)22(31)30(21)13-7-4-3-5-8-13/h3-12,15H,2H2,1H3,(H2,24,25,26,27,28)/t15-/m0/s1 |
Inchi Key | IFSDAJWBUCMOAH-HNNXBMFYSA-N |
SMILES | CCC(C1=NC2=C(C(=CC=C2)F)C(=O)N1C3=CC=CC=C3)NC4=NC=NC5=C4NC=N5 |
Size | 1mg |
Supplier Page | http://www.selleckchem.com/products/isosilybin-a.html |
Additional Information | https://file.selleck.cn/downloads/struct/E7972-Isosilybin-A-chemical-structure.png |