ML243
ML-243 is a selective inhibitor of cancer stem cells. Displays 32-fold selective inhibition of a breast cancer stem cell-like cell line (EC₅₀ = 2.0 µM) over a control (mammary epithelial) cell line (EC₅₀ = 64 µM). It weakly antagonizes the adenosine A2A receptor (IC50 = 10 µM) and has no effect on 68 other targets commonly used in drug discovery for lead profiling.
| Catalog Number | ABS-040 |
| Alternative Name(s) | (2E)-N-(4,5-dihydro-2-thiazolyl)-3-(4-ethylphenyl)-2-propenamide; CID-50910523 |
| CAS# | 1426576-80-8 |
| Inchi | InChI=1S/C14H16N2OS/c1-2-11-3-5-12(6-4-11)7-8-13(17)16-14-15-9-10-18-14/h3-8H,2,9-10H2,1H3,(H,15,16,17)/b8-7+ |
| Inchi Key | MTLJBAFNMHPGBV-BQYQJAHWSA-N |
| SMILES | CCC1=CC=C(C=C1)C=CC(=O)NC2=NCCS2 |
| Size | Inquiry |
| Supplier Page | https://www.agingclocks.com/ml243-item-1504.html |