Kenpaullone
Cell-permeable. A potent inhibitor of CDK1/cyclin B (IC50 = 400 nM), CDK2/cyclin A (IC50 = 680nM) , CDK5 (IC50 = 850nM) and with much less effect other kinases. In addition, it has been found to be a useful GSK-3β inhibitor (IC50 = 23nM). More recently, kenpaullone has been shown to increase neurogenesis of human neural progenitor cells through stimulation of Wnt/β-catenin signaling pathway.
| Catalog Number | ABS-034 |
| Alternative Name(s) | 9-Bromo-7,12-dihydroindolo-[3,2-d][1]benzazepin-6(5H)-one |
| CAS# | 142273-20-9 |
| Inchi | InChI=1S/C16H11BrN2O/c17-9-5-6-14-11(7-9)12-8-15(20)18-13-4-2-1-3-10(13)16(12)19-14/h1-7,19H,8H2,(H,18,20) |
| Inchi Key | QQUXFYAWXPMDOE-UHFFFAOYSA-N |
| SMILES | C1C2=C(C3=CC=CC=C3NC1=O)NC4=C2C=C(C=C4)Br |
| Size | Inquiry |
| Supplier Page | https://www.agingclocks.com/kenpaullone-item-1500.html |