GN44028
GN44028 is a potent and orally active hypoxia inducible factor (HIF)-1α inhibitor, with an IC50 of 14 nM. GN44028 inhibits hypoxia-induced HIF-1α transcriptional activity without suppressing HIF-1α mRNA expression, HIF-1α protein accumulation, or HIF-1α/HIF-1β heterodimerization. GN44028 can be used in the research of cancers.
| Catalog Number | E7505 |
| Molecular Formula | C18H20FN3O4 |
| CAS# | 1421448-26-1 |
| Inchi | InChI=1S/C18H20FN3O4/c1-10-9-26-17-14-11(16(23)12(18(24)25)8-22(10)14)7-13(19)15(17)21-5-3-20(2)4-6-21/h7-8,10H,3-6,9H2,1-2H3,(H,24,25)/t10-/m0/s1 |
| Inchi Key | GSDSWSVVBLHKDQ-JTQLQIEISA-N |
| SMILES | CC1COC2=C3N1C=C(C(=O)C3=CC(=C2N4CCN(CC4)C)F)C(=O)O |
| Size | 1mg |
| Supplier Page | http://www.selleckchem.com/products/gn44028.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E7505-GN44028-chemical-structure.png |