AZ5104
AZ5104, the demethylated metabolite of AZD-9291, is a potent EGFR inhibitor with IC50 of <1 nM, 6 nM, 1 nM, and 25 nM for EGFR (L858R/T790M), EGFR (L858R), EGFR (L861Q), and EGFR (wildtype), respectively. Phase 1.
| Trivial name | N/A |
| Catalog Number | S7298 |
| Molecular Formula | C27H31N7O2 |
| CAS# | 1421373-98-9 |
| Inchi | InChI=1S/C27H31N7O2/c1-6-26(35)30-22-15-23(25(36-5)16-24(22)34(4)14-13-33(2)3)32-27-28-12-11-21(31-27)19-17-29-20-10-8-7-9-18(19)20/h6-12,15-17,29H,1,13-14H2,2-5H3,(H,30,35)(H,28,31,32) |
| Inchi Key | IQNVEOMHJHBNHC-UHFFFAOYSA-N |
| SMILES | CN(C)CCN(C)C1=CC(=C(C=C1NC(=O)C=C)NC2=NC=CC(=N2)C3=CNC4=CC=CC=C43)OC |
| Size | 200mg |
| Supplier Page | http://www.selleckchem.com/products/az5104.html |
| Additional Information | https://file.selleck.cn/downloads/struct/az5104-chemical-structure-s7298.gif |